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”serotonin-fatigue hypothesis” is clear, several seemingly well-conducted studies have failed to . brain neurotransmitter systems (Meeusen and De Meirleir. Brain neurotransmitters in fatigue and overtraining. Romain Meeusen,ab Philip Watson,b Hiroshi Hasegawa,ac Bart Roelands,a Maria F. Such a change in neurotransmission has a direct impact on fatigue. sudden and profound central fatigue in athletes due to overtraining involves hypothalamic . These parts of the brain are also critical for evaluating and regulating external.

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It has been observed that the overtraining syndrome is generally caused by a sum of multiple stressing events in the life, such as physical training, sleep loss, exposition to stressing environments humidity, cold, altitude, and heatand change of residence, occupational pressures, and interpersonal difficulties.

These receptors have a fundamental role neurotrnsmitters the overtraining syndrome.

The overtraining can be distinguished in basedovoid sympathicotonic and Addisonian parasympathicotonic. Those studies with rats present uniformity Although the theoretical rationale for the “serotonin-fatigue hypothesis” is clear, several seemingly well-conducted studies have failed to support a significant role for 5-hydroxytryptamine in overtrauning development of fatigue.

Drix A, et al.

Brain neurotransmitters in fatigue and overtraining.

In resistance sports, the overtraining syndrome is characterized by a persistent fatigue and apathy. FATIGUE Fatigue can be defined as the set of manifestations produced by the work or prolonged exercises, which has as consequence a decreasing functional capability in keeping or continuing the expected outcome In the medical literature there are several meanings to the overtraining syndrome that generally are associated to the overloaded training, called overreaching.

Athletes of all performance levels may develop the syndrome, and a relevant number of signs and symptoms have been associated to it. The term stress means the status generated by the perception of the stimulus that cause emotional excitement, and upon the perturbation of the homeostasis, it triggers an adaptation process that is characterized among other changes by an increasing adrenaline secretion, producing several systemic manifestations with physiological and psychological disturbances The parasympathicotonic originated syndrome is characterized by predominant inhibition processes, physical weakness, and lack of motor activity.


Relationship of the overtraining syndrome with stress, fatigue, and serotonin

The recovery after loads is insufficient and late. Effect of n-3 fatty acids on free tryptophan and exercise fatigue. Overtraining in endurance athletes: Braz J Med Biol Res ; Am J Clin Nutr ; Its etiology has brought a great interest, mainly due to its multifactor feature, and it can be divided in two components: Peripheral alterations related to the overtraining syndrome can cause changing ovegtraining the secretion of hormones and in the sensitivity of the peripheral endocrine glandules.

External factors such as stress, interpersonal and environmental relationships have significant importance gatigue this context, and important parameters must be considered in evaluating situations whenever the overtraining is observed. The New American Library Inc. However, whenever it is detected a discrepancy between what is expected and what happened, the septo-hippocampal system starts in generating an inhibition of the behavior, an increasing vigilance level, driving the individual’s attention to possible sources of danger.

Fatigue is therefore probably an integrated phenomenon, with complex interaction among central and peripheral factors. Inadequate recovery from vigorous exercise. Br J Pharmacol ; It is possible that the energetic metabolism, which is secondary to the endocrine changes, be changed in oevrtraining overtraining syndrome, and thus, consequently affecting the fatigue as well.

Ribeiro L, Kapczinsk F.

In general, the muscular fatigue involves a lack of ability in generating energy in a sufficient amount o maintain a given neurotransmithers activity.

Effects of conditioned running on plasma, liver and brain tryptophan and on brain 5-hydroxytryptamine metabolism of the rat. The overtraining syndrome affects a considerable percentage of individuals involved in and resting intensive training programs. Decreased nocturnal catecholamine excretion: The resting athlete may present no symptoms, but these symptoms can supervene in a furtive and sudden way.


Several of these neurotransmitters are fatigje through precursors delivered by the food, and they are directly influenced by the diet.

It is essential that the necessary time to achieve the super-compensation is recognized.

This form of overtraining is easy to be diagnosed, since the athlete feels sick, and there are several indicator signs and symptoms, such as: Noradrenergic versus serotonergic antidepressants: On the other hand, high level athletes suffer the harmful consequences that ratigue from pressures provoked in the present context of the highly demanded sportive practice.

As brain function appears to be dependent upon the interaction of a number of systems, it is unlikely that a single neurotransmitter system is responsible for central fatigue. However, the big existing discrepancy between experimental protocols makes it difficulty to analyze the results. As the high serotoninergic activity during the stress leads to a high level of usage of the serotonin, the continuing stress can lead to a functional lack in the production of such neurotransmitter, and the deficiency of food originated precursors can decrease its cerebral synthesis 3.

Effects of acute physical exercise on central serotonergic systems. It has been demonstrated that the cerebral serotonin level depends on the free in the plasma tryptophan that increases whenever the free fatty acid concentration increases. Int J Sports Med ;13 Suppl 1: The GAS is composed by three phases: